If you are new to the IVF world, you may find it strange to hear that ovulation-blocking meds are routinely used. Wait…what? Isn’t the aim to get pregnant?!

Why are ovulation blocking medications used in IVF?

This class of medication are called Gonadotropin-Releasing Hormone (GnRH) Antagonists – meaning they block the pituitary gland from releasing Luteinizing Hormone (LH) and therefore blocking ovulation. The aim is to allow doctors to retrieve mature eggs with a catheter during an egg retrieval before the ovaries have a chance to naturally ovulate.

Before agonists, about 25% of all IVF stim rounds would be canceled due to early ovulation. The use and procedural development of medications  to controls the release of mature eggs from the ovaries has changed the IVF game.

How does Ganirelix and Cetrodite help?

The two main GnRH antagonist medications that block ovulation are Ganirelix and Cetrotide which are usually started after 5th or 6th day of the stimulation of the ovaries.

These medications are a popular choice because of its high success rates, easy administration and fewer side effects than using Lupron alone.